When a dangerous virus breaks out in Atlanta, under the supervision of Dr. Sabine Lommers (Claudia Black) set up a quarantine zone in the US metropolis to prevent the spread of the most contagious and potentially fatal disease. A brutal struggle for survival then begins for people within the isolated area, while many of them are separated from their loved ones. In order to keep control of the tense situation from outside, Lommers asks the police officer Alex Carnahan (David Gyasi) for help. The latter only agrees on the condition that he learns what is going on inside the quarantine zone, since both his girlfriend Jana (Christina Moses) and his friend Jake (Chris Wood) are there.
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