London, 1840. In the age before the discovery of anaesthetics, surgery is an agonising experience for terrified patients. Dr. Thomas Bolton (Boris Karloff) operates as quickly as he can to minimise the suffering, but is wracked with guilt when he discovers a traumatised amputee. Bolton determines to find a way to separate pain and the knife, although his son Jonathan (Francis Matthews) is doubtful that he will succeed. Bolton's efforts to achieve painless surgery lead him to experiment with chemicals that achieve only limited success. Confounded by his failure and mocked by his peers, Bolton experiments on himself, falling under the spell of the powerful gas he has created. He drifts into the murky world of Black Ben's lodging house, a wretched dive in London's Seven Dials. Ruthlessly manipulated by Black Ben (Francis de Wolff) and the graverobber Resurrection Joe (Christopher Lee), the hopelessly addicted Bolton is forced to pay a terrible price for his noble aspirations...
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