In his eagerness to create a revolutionary new drug, Doctor Timothy Straun (Andrew Divoff) has taken science to a new level of madness. He has no code of ethics and utilises the homeless and convicts as guinea pigs in his controversial research into human rage. Sometimes he even resorts to experimenting on himself. When Michael Dare 8Stephen Polk) is arrested for a crime he did not commit, he jumps at the chance to participate in Dr. Straun's research rather than go to jail. As the series of strange medical experiments commence, Michael together with the resident physician Susan Verger, realise that there may be something sinister about Straun's experiments and together they decide to investigate and confront whatever it is behind the bolted steel door in the basement.
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