Murder...Rage...Revenge...Deep in the jungle of Paraguay, Nazi zealot Dr. Martin Hoffmann (Stewart Granger) has been hiding for forty years, searching for a powerful weapon of science that will restore his dream of Nazi domination. Working with the venom of a deadly jungle spider, Hoffmann believes he has discovered such a weapon and, with his cohort Heinrich (George Lazenby), forms a plan to test his evil new serum on the population of Los Angeles; meanwhile, a dedicated band of Nazi-hunters, led by the beautiful Amanda (Maud Adams), is rapidly closing in on them.