In a span of 36 hours, Claudia Larson (Holly Hunter) has managed to lose her job, make out with her boss and learn that her daughter (Claire Danes) is planning to go all the way. But Claudia's fortunes actually take a turn for the worse when she flies home to endure an even more gruelling trial: the family Thanksgiving! Beset by a neurotic mother (Anne Bancroft), kooky father (Charles Durning), eccentric brother (Robert Downey Jr.) and compulsively "normal" sister (Cynthia Stevenson), Claudia struggles to maintain her calm. But as sparks fly, tempers flare and turkeys go airborne, Claudia manages to recapture the zaniness of her childhood and discover that the most important things in life are the memories she shares with family...and for that, she can only be thankful!
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