A film crew and actors arrive at the seemingly secure and beautiful Venetian hotel to film a version of the classic Jacobean tragedy. 'The Duchess of Malfi'. Shadowing the production are two rival entertainment reporters (Salma Hayek and Lucy Liu) who immediately start a war of egos. When the director (Rhys Ifans) is put out of commission, the producer (David Schwimmer) must take over the production, and that's when the cannibals and vampires start picking off the film crew and guests...
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