Detective Vernon Coyle (Adrian Pasdar), a detective with the Los Angeles Police Department, is trying to solve a series of bizarre murders. His girlfriend, Grace (Teri Polo), turns into a werewolf and is kidnapped by Crispian Grimes (Greg Wise), a vampire and owner of the nightclub House of Frankenstein. Meanwhile, a man, claiming to be Frankenstein's monster, comes to Los Angeles to find the vampire that killed his creator 200 years ago. He had lived in the Arctic Circle for centuries and had been thawed out recently. A medical examiner comes in and is shocked that he has no heartbeat and that his blood consists of that of several different people. The creature escapes and confronts Grimes in an alley, but gets arrested. Coyle realizes that the creature is really a creation of Frankenstein, and helps him track down Grimes and put a stop to his reign of terror. Grace turns into a werewolf and goes on a rampage, where she gets captured by Grimes and will be a part of his exhibit forever. Coyle and the creature destroy Grimes' army of the undead, but he escapes. The creature also escapes, having finally avenged his creator's death. He sneaks aboard a research vessel on its way to Antarctica. Grace revives after a successful blood transfusion makes her human again. Coyle and Grace later visit his partner's grave as he was the first victim of Grimes, who is watching them from afar.
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