The story centers on the O'Leary family, pioneer settlers whose eldest boys achieve notoriety and power in bustling Chicago. After Jack (Don Ameche) gets elected mayor with the help of his popular brother Dion (Tyrone Power), the two lock horns over the future of Chicago's slums. Using his cabaret singer wife (Alice Faye) as a pawn in their dispute, Dion accelerates their intense rivalry as the whole town takes sides. It is not until a massive fire wipes out all of old Chicago that the O'Learys' lives are changed forever.
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