November 2006. Alexander 'Sasha' Litvinenko (David Tennant), a former KGB officer, lies dying in a London hospital - poisoned by a mysterious radioactive substance. As Detective Inspector Brent Hyatt (Neil Maskell) is summoned to take his statement, Sasha directly accuses the Russian President, Vladimir Putin of orchestrating his murder. When Sasha dies a few days later, a team of Metropolitan Police officers led by Detective Superintendent Clive Timmons (Mark Bonnar), launch an investigation into what has become a chemical attack on the streets of London. As the police travel to Moscow to pursue the suspects, Sasha's devoted wife, Marina (Margarita Levieva), begins a ten-year fight against the British and Russian governments to find justice for his murder.
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