In Tallahassee Florida, four sexy party girls, billed by locals as the "House of Babes", are struggling to pay back a $20,000 loan for their post-feminist magazine, Biotch. Their grad-student neighbour, desperate for a thesis project for her masters in Women's Studies, persuades the household to fast off men for 100 days. In exchange, they'll receive $25,000 in grant money on order to save the magazine. Given the choice between men or their magazine, the women opt for the magazine. But when a multi-millionaire goes on national television and offers $1,000,000 to the first man who can break the fast, hordes of men converge on the small town for the Ultimate Woman Hunt.