Meet Monroe (James Nesbitt). A flawed but brilliant neurosurgeon. The stakes are always high in brain surgery and Monroe has no choice but to play the odds, faced every day with life or death decisions which cut across the lives of staff, patients and relatives. Monroe's rival, Jenny Bremner (Sarah Parish), is a straight laced heart surgeon who refuses to be charmed by Monroe's "twinkly self-regard". His anaesthetist, Lawrence Shepherd (Tom Riley), provides him with support, friendship, clinical judgement and, best of all, a punch line to all his jokes. Monroe would be the first to admit that the demands of his job mean his home life has suffered. But what he doesn't know is that's about to become a whole lot worse...
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