"Nate and Margaret" centers on a 19-year-old film student named Nate (Tyler Ross) and his best friend Margaret (Natalie West), a 52-year-old spinster who dreams of being a stand-up comedian. Nate's audacious classmate Darla (Gaby Hoffmann) sets him up on a date with James (Conor McCahill), which causes Nate's new life to shake apart his friendship with Margaret, who must now go find a life of her own.
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