Julianne Moore gives an astonishing performance as Carol White, a typically bored, affluent Californian housewife whose carefully controlled domestic environment suddenly turns against her. Gradually she develops nosebleeds, vomiting and breathing problems before finally collapsing. In desperation to remain 'safe' from her allergies she opts for the virtual isolation of a porcelain igloo in the Texan desert where the inhabitants drag around oxygen cylinders and therapists behave like preachers.
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