Going to school and working several jobs to support his family is bringing down Darryl Witherspoon (Marlon Wayans). Things take a crazy turn when he participates in a medical study for extra cash and the experimental drug he's taking blows his senses out of whack. Now, with superhuman sight, smell, hearing, taste and touch, Darryl just may be able to get even with rich, arrogant frat boy Scott Thorpe (David Spade), who's been giving him grief.