Charlie Berns (William H Macy) is a veteran Hollywood movie producer who has given up on his career and life. This is until his idealistic screenwriter nephew comes up with the script of a lifetime and Charlie decides to give his career one final shot. The only thing standing in his way is Diedre Hearn (Meg Ryan), a sharp witted studio executive brought in to keep Charlie in line. But when their A-list action star gets kidnapped and the studio shuts down their movie they reluctantly team up to pull off one of the biggest hustles in Hollywood history.
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