After years of pursuing psychotic killers in Los Angeles, FBI agent Joel Campbell (James Spader) wants out. And now his nemesis, serial killer David Allen Griffin (Keanu Reeves), has tracked him all the way to Chicago just to torment him. Before each murder, Griffin sends Campbell a photograph of his intended victim and dares him to find her before he strikes again. Now, with every tick of the clock, and amidst pulse-pounding action, this stone-cold killer turns up the heat.