Eight years have passed since the events of Ek Tha Tiger and the whereabouts of Tiger (Salman Khan) and Zoya (Katrina Kaif) are not known. In Ikrit, Syria, 40 nurses - 25 Indian and 15 Pakistani - are held hostage in their own hospital by Abu Usman (Sajjad Delafrooz), the head of ISC, a terrorist organisation. The chairman of the Research and Analysis Wing (RAW), Shenoy (Girish Karnad), feels that only Tiger would be able to rescue the nurses and that too within a period of 7 days as the United States will launch an airstrike within 7 days to kill Usman. Presently, Tiger and Zoya live in Innsbruck, Austria and have a son, Junior (Sartaaj Kakkar).