Lifelong friends Amelia (Catherine Keener) and Laura (Anne Heche) are at a crossroads in their lives. Amelia is single and in therapy, while Laura, herself a therapist, is due to marry her boyfriend Frank. However, Amelia's attempts at dating a nerdish video store clerk end in disaster, and Laura's imminent wedding comes under threat from an obsession that she has formed with a mole on Frank's chest.
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